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Regulation of noncoding RNAs in innate lymphoid cells

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References

  1. Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, et al. Innate lymphoid cells: 10 years on. Cell. 2018;174:1054–66.

    Article  CAS  PubMed  Google Scholar 

  2. Wang S, Xia P, Chen Y, Qu Y, Xiong Z, Ye B, et al. Regulatory innate lymphoid cells control innate intestinal inflammation. Cell. 2017;171:201–216.e218.

    Article  CAS  PubMed  Google Scholar 

  3. Walker JA, Clark PA, Crisp A, Barlow JL, Szeto A, Ferreira A, et al. Polychromic reporter mice reveal unappreciated innate lymphoid cell progenitor heterogeneity and elusive ILC3 progenitors in the bone marrow. Immunity. 2019;51:104–118.e107.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Liu B, Liu N, Zhu X, Yang L, Ye B, Li H, et al. Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA. Cell Mol Immunol. 2021;18:1412–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Liu CX, Chen LL. Circular RNAs: Characterization, cellular roles, and applications. Cell. 2022;185:2390.

    Article  CAS  PubMed  Google Scholar 

  6. Liu N, He J, Fan D, Gu Y, Wang J, Li H, et al. Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. Nat Commun. 2022;13:4711.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Liu B, Ye B, Zhu X, Yang L, Li H, Liu N, et al. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. Nat Commun. 2020;11:4076.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Zhu P, Zhu X, Wu J, He L, Lu T, Wang Y, et al. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 2019;20:183–94.

    Article  CAS  PubMed  Google Scholar 

  9. Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, et al. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by the initiation of Zfp292 expression. Nat Immunol. 2017;18:499–508.

    Article  CAS  PubMed  Google Scholar 

  10. Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, et al. Group 1 innate lymphoid cell lineage identity is determined by a cis-regulatory element marked by a long non-coding RNA. Immunity. 2017;47:435–449.e438.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Berrien-Elliott MM, Sun Y, Neal C, Ireland A, Trissal MC, Sullivan RP, et al. MicroRNA-142 is critical for the homeostasis and function of Type 1 innate lymphoid cells. Immunity. 2019;51:479–490.e476.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, et al. MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. J Exp Med. 2017;214:3627–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Roberts LB, Jowett GM, Read E, Zabinski T, Berkachy R, Selkirk ME, et al. MicroRNA-142 critically regulates group 2 innate lymphoid cell homeostasis and function. J Immunol. 2021;206:2725–39.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Zhu Y, Liu Y, Zhu X, Wang Z, Wang M. Upregulation of miR-155 regulates group 2 innate lymphoid cells by targeting c-maf in allergic rhinitis. Eur J Pharm. 2020;887:173564.

    Article  CAS  Google Scholar 

  15. Zhang L, Meng W, Chen X, Ning Y, Sun M, Wang R. MiR-150-5p regulates the functions of type 2 innate lymphoid cells via the ICAM-1/p38 MAPK axis in allergic rhinitis. Mol Cell Biochem. 2022;477:1009–22.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by the National Key R&D Program of China (2021YFA1302000, 2020YFA0803501), the National Natural Science Foundation of China (32170874, 81921003, 31930036) and Joint Funding of Henan Provincial Science and Technology R&D Plan (222301420015).

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BL, LZ, PZ, and ZF drafted and edited the manuscript. BL and ZF performed the final proofreading of the manuscript.

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Correspondence to Benyu Liu or Zusen Fan.

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The authors declare no competing interests.

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Liu, B., Zhang, L., Zhu, P. et al. Regulation of noncoding RNAs in innate lymphoid cells. Cell Mol Immunol 20, 543–545 (2023). https://doi.org/10.1038/s41423-023-00993-3

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