Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or hepatocellular carcinoma (HCC) and accounting for many deaths each year. The pathogenesis of hepatic fibrosis/cirrhosis is very complex, which makes treatment challenging. Endogenous mesenchymal stromal cells (MSCs) have been shown to play pivotal roles in the pathogenesis of hepatic fibrosis. Paradoxically, exogenous MSCs have also been used in clinical trials for liver cirrhosis, and their effectiveness has been observed in most completed clinical trials. There are still many issues to be resolved to promote the use of MSCs in the clinic in the future. In this review, we will examine the controversial role of MSCs in the pathogenesis and treatment of hepatic fibrosis/cirrhosis. We also investigated the clinical trials involving MSCs in liver cirrhosis, summarized the parameters that need to be standardized, and discussed how to promote the use of MSCs from a clinical perspective.
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This project was supported by the National Key R&D Program of China (Grant No. 2018YFA0107500), the National Natural Science Foundation of China (Grant Nos. 82173276, 81972599, 81930085, 82073032, 82073037, and 81872243) and Grant No. 2022YFA0807300.
The authors declare no competing interests.
The original online version of this article was revised: In this article the legends for all the figures were inadvertently omitted. The original article has been corrected.
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Yang, X., Li, Q., Liu, W. et al. Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment. Cell Mol Immunol 20, 583–599 (2023). https://doi.org/10.1038/s41423-023-00983-5
- Mesenchymal stromal cells
- Hepatic fibrosis/cirrhosis
- Clinical application
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