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Group 3 innate lymphoid cells: intestinal patrolling guardians bullied by T cells

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References

  1. Domingues RG, Hepworth MR. Immunoregulatory sensory circuits in group 3 innate lymphoid cell (ILC3) function and tissue homeostasis. Front Immunol. 2020;11:116.

    Article  CAS  Google Scholar 

  2. Jarade A, Garcia Z, Marie S, Demera A, Prinz I, Bousso P, et al. Inflammation triggers ILC3 patrolling of the intestinal barrier. Nat Immunol. 2022;23:1317–23.

    Article  CAS  Google Scholar 

  3. Zhou W, Sonnenberg GF. Activation and suppression of group 3 innate lymphoid vells in the gut. Trends Immunol. 2020;41:721–33.

    Article  CAS  Google Scholar 

  4. Sonnenberg GF, Hepworth MR. Functional interactions between innate lymphoid cells and adaptive immunity. Nat Rev Immunol. 2019;19:599–613.

    Article  CAS  Google Scholar 

  5. Deng T, Suo C, Chang J, Yang R, Li J, Cai T, et al. ILC3 -derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice. Cell Mol Immunol. 2020;17:163–77.

  6. Hepworth MR, Monticelli LA, Fung TC, Ziegler CGK, Grunberg S, Sinha R, et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. 2013;498:113–7.

    Article  CAS  Google Scholar 

  7. Rao A, Strauss O, Kokkinou E, Bruchard M, Tripathi KP, Schlums H, et al. Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs. Nat Commun. 2020;11:2049.

    Article  CAS  Google Scholar 

  8. Zhou L, Chu C, Teng F, Bessman NJ, Goc J, Santosa EK, et al. Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature. 2019;568:405–9.

    Article  CAS  Google Scholar 

  9. Bruchard M, Geindreau M, Perrichet A, Truntzer C, Ballot E, Boidot R, et al. Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses. Nat Immunol. 2022;23:262–74.

    Article  CAS  Google Scholar 

  10. Bauché D, Joyce-Shaikh B, Jain R, Grein J, Ku KS, Blumenschein WM, et al. LAG3(+) Regulatory T cells restrain lnterleukin-23-producing CX3CR1(+) gut-resident macrophages during group 3 innate lymphoid cell-driven colitis. Immunity. 2018;49:342–52.e345.

    Article  Google Scholar 

  11. Mackley EC, Houston S, Marriott CL, Halford EE, Lucas B, Cerovic V, et al. CCR7-dependent trafficking of RORgamma(+) ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nat Commun. 2015;6:5862.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by the grants from the National Key Research and Development Program [grant number 2021YFF0704805], and the Scientific and Technological Development Plan of Jilin Province [grant number 20210402009GH].

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Correspondence to Jingtao Chen.

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Lv, X., Zhu, S., Wu, J. et al. Group 3 innate lymphoid cells: intestinal patrolling guardians bullied by T cells. Cell Mol Immunol 20, 115–116 (2023). https://doi.org/10.1038/s41423-022-00948-0

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