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Spatiotemporal mapping of the leprosy granuloma landscape

Cellular & Molecular Immunology volume 19, pages 558–560 (2022)Cite this article

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Leprosy is a chronic infectious disease of humans caused by Mycobacterium leprae (M. leprae) that is prevalent in some countries of Asia, Africa, and South America [1].

Leprosy has traditionally been classified into two major types, tuberculoid and lepromatous. Patients with tuberculoid leprosy (T-LEP) have limited disease with relatively few bacteria in the skin and nerves and can successfully control the infection. In contrast, lepromatous leprosy (L-LEP) patients have widespread disease and a large number of bacteria. Indeed, this disease spectrum is dynamic since patients may undergo a reversal reaction (RR) and generally upgrade, either spontaneously or during chemotherapy, from L-LEP to T-LEP [2].

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Acknowledgements

This research was supported by institutional funds from the University of Palermo.

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Authors and Affiliations

  1. Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, Italy

    Marco P. La Manna, Francesco Dieli & Nadia Caccamo

  2. Department of Biomedicine, Neurosciences and Advanced Diagnosis, University of Palermo, Palermo, Italy

    Marco P. La Manna, Francesco Dieli & Nadia Caccamo

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  1. Marco P. La Manna
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  2. Francesco Dieli
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  3. Nadia Caccamo
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Correspondence to Francesco Dieli.

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La Manna, M.P., Dieli, F. & Caccamo, N. Spatiotemporal mapping of the leprosy granuloma landscape. Cell Mol Immunol 19, 558–560 (2022). https://doi.org/10.1038/s41423-021-00826-1

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  • DOI: https://doi.org/10.1038/s41423-021-00826-1

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