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Altered expression of glymphatic system-related proteins in prion diseases: Implications for the role of the glymphatic system in prion diseases

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  1. Prusiner SB. The prion diseases. Brain Pathol. 1998;8:499–513.

    Article  CAS  Google Scholar 

  2. Rodriguez A, Perez-Gracia E, Espinosa JC, Pumarola M, Torres JM, Ferrer I. Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice. Acta Neuropathol. 2006;112:573–85.

    Article  CAS  Google Scholar 

  3. Costa C, Tortosa R, Rodriguez A, Ferrer I, Torres JM, Bassols A, et al. Aquaporin 1 and aquaporin 4 overexpression in bovine spongiform encephalopathy in a transgenic murine model and in cattle field cases. Brain Res. 2007;1175:96–106.

    Article  CAS  Google Scholar 

  4. Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Ito M, Kitamoto T, et al. Enhanced Aquaporin-4 immunoreactivity in sporadic Creutzfeldt-Jakob disease. Neuropathology. 2007;27:314–23.

    Article  Google Scholar 

  5. Hablitz LM, Pla V, Giannetto M, Vinitsky HS, Staeger FF, Metcalfe T, et al. Circadian control of brain glymphatic and lymphatic fluid flow. Nat. Commun. 2020;11:4411.

    Article  CAS  Google Scholar 

  6. Wolburg H, Noell S, Wolburg-Buchholz K, Mack A, Fallier-Becker P. Agrin, aquaporin-4, and astrocyte polarity as an important feature of the blood-brain barrier. Neuroscientist. 2009;15:180–93.

    Article  CAS  Google Scholar 

  7. Lilius TO, Blomqvist K, Hauglund NL, Liu G, Staeger FF, Baerentzen S, et al. Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs. J. Control Rel. 2019;304:29–38.

    Article  CAS  Google Scholar 

  8. Feng ZX, Dong H, Qu WM, Zhang W. Oral delivered dexmedetomidine promotes and consolidates non-rapid eye movement sleep via sleep-wake regulation systems in mice. Front Pharm. 2018;9:1196.

    Article  CAS  Google Scholar 

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This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2021R1A2C1013213). This research was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education (2017R1A6A1A03015876). This work was supported by an NRF (National Research Foundation of Korea) Grant funded by the Korean Government (NRF-2019-Fostering Core Leaders of the Future Basic Science Program/Global Ph.D. Fellowship Program). SYW and YCK were supported by the BK21 Plus Program in the Department of Bioactive Material Sciences.

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YCK, SYW and BHJ conceived and designed the experiment. YCK and SYW performed the experiments. YCK, SYW and BHJ analyzed the data. YCK, SYW and BHJ wrote the paper. All authors read and approved the final manuscript.

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Correspondence to Byung-Hoon Jeong.

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Kim, YC., Won, SY. & Jeong, BH. Altered expression of glymphatic system-related proteins in prion diseases: Implications for the role of the glymphatic system in prion diseases. Cell Mol Immunol 18, 2281–2283 (2021).

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