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The hepatic macrophage pool in NASH

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Fig. 1

References

  1. 1.

    Tacke, F. & Yoneyama, H. From NAFLD to NASH to fibrosis to HCC: role of dendritic cell populations in the liver. Hepatology 58, 494–496 (2013).

    CAS  Article  Google Scholar 

  2. 2.

    Krenkel, O. & Tacke, F. Liver macrophages in tissue homeostasis and disease. Nat. Rev. Immunol. 17, 306–321 (2017).

    CAS  Article  Google Scholar 

  3. 3.

    Ju, C. & Tacke, F. Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cell. Mol. Immunol. 13, 316–327 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Tran, S. et al. Impaired Kupffer cell self-renewal alters the liver response to lipid overload during non-alcoholic steatohepatitis. Immunity 53, 627–640 (2020). e625.

    Article  Google Scholar 

  5. 5.

    Remmerie, A. et al. Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver. Immunity 53, 641–657 (2020).

    Article  Google Scholar 

  6. 6.

    Seidman, J. et al. Niche-specific reprogramming of epigenetic landscapes drives myeloid cell diversity in nonalcoholic steatohepatitis. Immunity 52, 1057–1074 (2020).

    CAS  Article  Google Scholar 

  7. 7.

    Krenkel, O. et al. Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis. Hepatology 67, 1270–1283 (2018).

    CAS  Article  Google Scholar 

  8. 8.

    Morikawa, R. et al. Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis. J. Hepatol. 74, 511–521 (2021).

    CAS  Article  Google Scholar 

  9. 9.

    Guo, Q. et al. Integrin β-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH. J. Hepatol. 71, 1193–1205 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Cai, B. et al. Macrophage MerTK promotes liver fibrosis in nonalcoholic steatohepatitis. Cell Metab. 31, 406–421 (2020).

    CAS  Article  Google Scholar 

  11. 11.

    Wang, Y. et al. Overexpression of TIM-3 in macrophages aggravates pathogenesis of pulmonary fibrosis in mice. Am. J. Resp. Cell Mol. Biol. 61, 727–736 (2019).

    CAS  Article  Google Scholar 

  12. 12.

    Du, X. et al. Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice. Cell. Mol. Immunol. 16, 878–886 (2019).

    CAS  Article  Google Scholar 

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Correspondence to Chunhong Ma.

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Wang, T., Ma, C. The hepatic macrophage pool in NASH. Cell Mol Immunol (2021). https://doi.org/10.1038/s41423-021-00690-z

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