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Dynamic regulation of innate lymphoid cells in the mucosal immune system

Cellular & Molecular Immunology volume 18, pages 1387–1394 (2021)Cite this article

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Abstract

The mucosal immune system is considered a local immune system, a term that implies regional restriction. Mucosal tissues are continually exposed to a wide range of antigens. The regulation of mucosal immune cells is tightly associated with the progression of mucosal diseases. Innate lymphoid cells (ILCs) are abundant in mucosal barriers and serve as first-line defenses against pathogens. The subtype changes and translocation of ILCs are accompanied by the pathologic processes of mucosal diseases. Here, we review the plasticity and circulation of ILCs in the mucosal immune system under physiological and pathological conditions. We also discuss the signaling pathways involved in dynamic ILC changes and the related targets in mucosal diseases.

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Acknowledgements

This work was supported by the Strategic Priority Research Programs of the Chinese Academy of Sciences (XDB29020000), the National Natural Science Foundation of China (81722023, 81922031), the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (ZDBS-LY-SM025), the Beijing Natural Science Foundation (7212067), and the Youth Innovation Promotion Association of CAS to S.W.

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  1. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    Fei Shao, Dou Yu & Shuo Wang

  2. University of Chinese Academy of Sciences, Beijing, China

    Fei Shao & Shuo Wang

  3. Division of Life Sciences of Medicine, University of Science and Technology of China, Hefei, China

    Dou Yu

  4. Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China

    Pengyan Xia

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Shao, F., Yu, D., Xia, P. et al. Dynamic regulation of innate lymphoid cells in the mucosal immune system. Cell Mol Immunol 18, 1387–1394 (2021). https://doi.org/10.1038/s41423-021-00689-6

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