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Differences in IFNβ secretion upon Rab1 inactivation in cells exposed to distinct innate immune stimuli

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (31830022 and 81621001) and the Chinese Ministry of Science and Technology (2019YFA0508500). X.Z. was supported by the National Natural Science Foundation of China (31800752). We thank Dr. Jianzhong Xi (Peking University) for hCas9 and gRNA expression vectors; Dr. Mitsunori Fukuda (Tohoku University) for mouse Rab expression vectors; Dr. Hongbing Shu (Wuhan University) for the human MAVS expression vector; Dr. Jianguo Chen (Peking University) for the peYFP-Golgi expression vector; Dr. Congyi Zheng (Wuhan University) for SeV; and Drs. Yulong Li and Jianli Tao (Peking University) for critical discussions.

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J.Y. and Z.J. designed the research; J.Y. performed the majority of the experiments; X.Z., R.Z., H.S., and F.Y. assisted in some experiments, including the construct preparations; J.Y., X.Z., and Z.J. analyzed the data and wrote the paper.

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Correspondence to Zhengfan Jiang.

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Yang, J., Zhou, X., Zhang, R. et al. Differences in IFNβ secretion upon Rab1 inactivation in cells exposed to distinct innate immune stimuli. Cell Mol Immunol 18, 1590–1592 (2021). https://doi.org/10.1038/s41423-021-00659-y

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