Fig. 4 | Cellular & Molecular Immunology

Fig. 4

From: Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Fig. 4

Cross-reactivity of the RBD-targeting neutralizing mAbs against SARS-CoV and SARS-CoV-2. a Characteristics of the neutralizing mAbs against the SARS CoV-2 RBD and SARS CoV RBD. b, c Dose-dependent binding of SARS-CoV and SARS-CoV-2 mAbs to the SARS-CoV RBD (b) or SARS-CoV-2 RBD (c) as determined by ELISA. Isotype antibody was included as a control. Data are presented as the mean OD450 ± s.e.m. (n = 2). d, e Dose-dependent competition of the SARS-CoV-2 or SARS-CoV mAbs and hACE2 with the SARS-CoV RBD (d) or SARS-CoV-2 RBD (e) as measured by ELISA. Data are presented as the mean OD450 ± s.e.m. (n = 2). f IC50 values were determined for a panel of mAbs neutralizing the SARS-CoV-2 or SARS-CoV pseudo-typed viruses. Representative data are shown

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