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CD226: a potent driver of antitumor immunity that needs to be maintained

Cellular & Molecular Immunology volume 19, pages 969–970 (2022)Cite this article

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CD226 (DNAX Accessory Molecule-1, DNAM-1, PTA-1, TLiSA1) is a transmembrane protein that is expressed on T cells, natural killer (NK) cells, B cells, monocytes, and platelets. CD226, together with the inhibitory receptors TIGIT and CD96, belongs to a cell-surface receptor family3 that binds nectin and nectin-like proteins. The interesting feature of this family is that these receptors compete for common ligands. For example, CD226 competes with TIGIT and CD96 for binding to CD155 (Nectin-like molecule 5, Necl-5, PVR) and CD112 (Nectin-2), and the expression of these ligands is usually abundant in tumors.

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Acknowledgements

This work was supported by the National Key R&D Program of China (2020YFA0710802) and the Natural Science Foundation of China (reference number 82071768).

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  1. CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

    Jiacheng Bi

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Bi, J. CD226: a potent driver of antitumor immunity that needs to be maintained. Cell Mol Immunol 19, 969–970 (2022). https://doi.org/10.1038/s41423-020-00633-0

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  • DOI: https://doi.org/10.1038/s41423-020-00633-0

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