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The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer

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This research is supported by grants from the National Natural Science Foundation for Key Programs of China (31730024, G.L.), the National Natural Science Foundation for General Programs of China (31671524, G.L.), and the Beijing Municipal Natural Science Foundation of China (5202013, GL).

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A.J., Y.B., and Y.X.W. designed and conducted the mouse and cell experiment and analyzed the data; Y.F.W., Y.L., Q.Y. Y.C., Y.H., L.D., Y.D., Y.H., and R.W. participated in discussions; R.W. and Y.B. contributed to writing the manuscript; and G.L. developed the concept, designed and conducted the experiments, analyzed the data, wrote the manuscript, and provided overall direction.

Corresponding authors

Correspondence to Ruoning Wang or Yujing Bi or Guangwei Liu.

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The authors declare no competing interests.

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The present study was approved by the Ethics Committee of the College of Life Science of Beijing Normal University, Beijing China.

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Jia, A., Wang, Y., Wang, Y. et al. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol (2021).

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