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Functional phenotypes of CCR5 on CD4+ T cells of relevance to its genetic and epigenetic associations with HIV infection

Cellular & Molecular Immunology volume 17, pages 680–681 (2020)Cite this article

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The article by Kulkarni et al. provides a description of some genetic and epigenetic interactions that determine the functional phenotypes of the chemokine receptor CCR5, which is critical to human immunodeficiency virus type 1 (HIV-1) infection.1

Significant advances in the genetic regulation of human diseases have been made through the use of genome-wide association studies (GWASs) over the past several years. The daunting task of elucidating the cellular pathways that are critical to human disease regulation remains for many disease-associated coding genetic variants.2

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Authors and Affiliations

  1. Department of Biochemistry, Microbiology and Immunology, Wayne State University, School of Medicine, Detroit, MI, USA

    Dusanka S. Skundric, Harley Y. Tse & Paul C. Montgomery

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  1. Dusanka S. Skundric
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  2. Harley Y. Tse
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  3. Paul C. Montgomery
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Correspondence to Dusanka S. Skundric.

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The authors declare that they have no competing interests. DSS conceived idea and wrote the commentary. HYT and PCM contributed by critical reading of the manuscript. All authors read and approved the manuscript.

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Skundric, D.S., Tse, H.Y. & Montgomery, P.C. Functional phenotypes of CCR5 on CD4+ T cells of relevance to its genetic and epigenetic associations with HIV infection. Cell Mol Immunol 17, 680–681 (2020). https://doi.org/10.1038/s41423-019-0342-x

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