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Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells

Cellular & Molecular Immunology volume 17, pages 547–549 (2020)Cite this article

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Interferons (IFNs) are “warning signal” cytokines released upon pathogen sensing. IFNs control the expression of interferon-stimulated genes (ISGs), which are often crucial to restrict viral infections and establish a cellular antiviral state.1,2 Langerin (CD207), a well-known surface receptor on Langerhans cells (LC), belongs to the C-type lectin receptor (CLR) family and constitutes a major pathogen binding receptor able to regulate both innate and adaptive immune responses.3,4 Importantly, this CLR was reported as an antiviral receptor, notably able to bind and internalize incoming human immunodeficiency virus (HIV) virions in Birbeck granules for degradation.5,6 However, langerin was never viewed as a contributor to the interferon-mediated antiviral immune response. We now provide evidence that langerin is an ISG showing upregulated expression upon IFN treatment in monocyte-derived and ex vivo human skin-isolated LCs.

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References

  1. Doyle, T., Goujon, C. & Malim, M. H. HIV-1 and interferons: who’s interfering with whom? Nat. Rev. Microbiol. 13, 403–413 (2015).

    Article  CAS  Google Scholar 

  2. Schneider, W. M., Chevillotte, M. D. & Rice, C. M. Interferon-stimulated genes: a complex web of host defenses. Annu. Rev. Immunol. 32, 513–545 (2014).

    Article  CAS  Google Scholar 

  3. Merad, M., Ginhoux, F. & Collin, M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat. Rev. Immunol. 8, 935–947 (2008).

    Article  CAS  Google Scholar 

  4. Valladeau, J. et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12, 71–81 (2000).

    Article  CAS  Google Scholar 

  5. de Witte, L. et al. Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. Nat. Med. 13, 367–371 (2007).

    Article  Google Scholar 

  6. van der Vlist, M. & Geijtenbeek, T. B. Langerin functions as an antiviral receptor on Langerhans cells. Immunol. Cell Biol. 88, 410–415 (2010).

    Article  Google Scholar 

  7. Burrone, O. R., Kefford, R. F., Gilmore, D. & Milstein, C. Stimulation of HLA-A,B,C by IFN-alpha. The derivation of Molt 4 variants and the differential expression of HLA-A,B,C subsets. EMBO J. 4, 2855–2860 (1985).

    Article  CAS  Google Scholar 

  8. Czubala, M. A. et al. TGFbeta induces a SAMHD1-independent post-entry restriction to HIV-1 infection of human epithelial Langerhans cells. J. Invest. Dermatol. 136, 1981–1989 (2016).

    Article  CAS  Google Scholar 

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Acknowledgements

We thank Richard O.S. Karoo and the members of Spire Cardiff Hospital (Wales, UK) for providing skin samples. We are grateful to J. Paul Mitchell, Sion A. Coulman (Cardiff, Wales, UK), and all members of the Viral Trafficking, Restriction and Innate Signaling Team for excellent technical help and/or critical reading of the manuscript. We are also grateful to Caroline Goujon and Olivier Moncorgé (IRIM, Montpellier, France) for the kind gift of reagents. Immunofluorescence imaging and some of the flow cytometry acquisitions were performed at Montpellier RIO Imaging (Montpellier, France). This work was supported in part by an ANRS grant (No. D15236) to F.P.B. This work was also supported by the Cardiff University President’s Research Scholarship to M.A.C. and grants from ISSF-WT and the Gates Foundation to V.P. G.M. was the recipient of a postdoctoral fellowship from Labex EpiGenMed (Montpellier, France) and is currently supported by the ANRS. The funding bodies had no role in the preparation of the article, design of the study, or interpretation of the data.

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Author notes

  1. These authors contributed equally: Ghizlane Maarifi, Magdalena A. Czubala

Authors and Affiliations

  1. Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, CNRS, Montpellier, France

    Ghizlane Maarifi, Justine Lagisquet, Kyra Fuchs, Laure Papin, Sébastien Nisole & Fabien P. Blanchet

  2. Systems Immunity University Research Institute and Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK

    Magdalena A. Czubala, Matthew O. Ivory & Vincent Piguet

  3. School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK

    Matthew O. Ivory & James C. Birchall

  4. Division of Dermatology, Women’s College Hospital, Toronto, Canada

    Vincent Piguet

  5. Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada

    Vincent Piguet

Authors
  1. Ghizlane Maarifi
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  10. Fabien P. Blanchet
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Contributions

M.A.C., G.M., and F.P.B. conceived the study. J.C.B., V.P., S.N., and F.P.B. assisted with the experimental design or provided reagents. M.A.C., G.M., J.L., M.O.I., K.F., L.P., and F.P.B. carried out the experiments; and F.P.B. wrote the manuscript. All authors read and commented on the manuscript.

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Correspondence to Fabien P. Blanchet.

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Maarifi, G., Czubala, M.A., Lagisquet, J. et al. Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. Cell Mol Immunol 17, 547–549 (2020). https://doi.org/10.1038/s41423-019-0302-5

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