Rubicon: a facilitator of viral immune evasion

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References

  1. 1.

    Wan, Y. et al. Inducible Rubicon facilitates viral replication by antagonizing interferon production. Cell Mol. Immunol. 14, 607–620 (2017).

  2. 2.

    Isaacs, A. & Lindenmann, J. Virus interference. I. The interferon. Proc. R. Soc. Lond. 147, 258–267 (1957).

  3. 3.

    Perkins, N. D. Integrating cell-signalling pathways with NF-κB and IKK function. Nat. Rev. Mol. Cell Biol. 8, 49–62 (2007).

  4. 4.

    Rahighi, S. et al. Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation. Cell 136, 1098–1109 (2009).

  5. 5.

    Brady, G., Haas, D. A., Farrell, P. J., Pichlmair, A. & Bowie, A. G. Molluscum contagiosum virus protein MC005 inhibits NF-kappaB activation by targeting NEMO-regulated IkappaB kinase activation. J. Virol. 91, 15 (2017).

  6. 6.

    Wong, S. W., Sil, P. & Martinez, J. Rubicon: LC3-associated phagocytosis and beyond. FEBS J. 285, 1379–1388 (2018).

  7. 7.

    Yang, C. S. et al. The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity. Cell Host Microbe 11, 277–289 (2012).

  8. 8.

    Wang, L., Tian, Y. & Ou, J. H. HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication. PLoS Pathog. 11, e1004764 (2015).

  9. 9.

    Kim, J. H. et al. Rubicon modulates antiviral type I interferon (IFN) signaling by targeting IFN regulatory factor 3 dimerization. J. Virol. 91, e00248–17 (2017).

  10. 10.

    Hiscott, J. Triggering the innate antiviral response through IRF-3 activation. J. Biol. Chem. 282, 15325–15329 (2007).

  11. 11.

    Vincendeau, M. Inhibition of canonical NF-kappaB signaling by a small molecule targeting NEMO-ubiquitin interaction. Sci. Rep. 6, 18934 (2016).

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Correspondence to Shi Liu.

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Fang, P., Yu, H., Li, M. et al. Rubicon: a facilitator of viral immune evasion. Cell Mol Immunol 16, 770–771 (2019). https://doi.org/10.1038/s41423-019-0248-7

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