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Peripheral memory T cells specific for Arginase-1

Cellular & Molecular Immunology volume 16, pages 718–719 (2019)Cite this article

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Increased arginase-1 (Arg-1) activity is one of the common mechanisms of immune inhibition in patients with cancer. Arg-1 is an enzyme catalyzing the first step in L-arginine metabolism and is expressed by various immunosuppressive myeloid cells as well as by cancer cells. Arg-1-associated deprivation of l-arginine downregulates the expression of the T cell receptor ζ chain and decreases cytokine production and proliferation of activated T cells.1,2

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References

  1. Singhal, S. et al. Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Sci. Transl. Med. 11, 11–479 (2019).

    Article  Google Scholar 

  2. Vanpouille-Box, C. & Formenti, S. C. Dual transforming growth factor-beta and programmed death-1 blockade: a strategy for immune-excluded tumors? Trends Immunol. 39, 435–437 (2018).

    Article  CAS  Google Scholar 

  3. Martinenaite, E. et al. Frequent spontaneous adaptive immune responses towards arginase. Oncoimmunology 7, e1404215 (2017).

    Article  Google Scholar 

  4. Keilholz, U. et al. Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy. J. Immunother. 25, 97–138 (2002).

    Article  Google Scholar 

  5. Andersen, M. H. The balance players of the adaptive immune system. Cancer Res. 78, 1379–1382 (2018).

    Article  CAS  Google Scholar 

  6. Cassetta, L. & Pollard, J. W. Targeting macrophages: therapeutic approaches in cancer. Nat. Rev. Drug Discov. 17, 887–904 (2018).

  7. Yu, W. et al. Clonal deletion prunes but does not eliminate self-specific alphabeta CD8(+) T lymphocytes. Immunity 19;42, 929–941 (2015).

    Article  Google Scholar 

  8. Sorensen, R. B. et al. Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators. Blood 117, 2200–2210 (2011).

    Article  Google Scholar 

  9. Munir, S. et al. HLA-restricted cytotoxic T cells that are specific for the immune checkpoint ligand PD-L1 occur with high frequency in cancer patients. Cancer Res. 73, 1674–1776 (2013).

    Article  Google Scholar 

  10. Andersen, M. H. Immune regulation by self-recognition: novel possibilities for anticancer immunotherapy. J. Natl. Cancer Inst. 107, 154 (2015).

    Article  Google Scholar 

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Authors and Affiliations

  1. Center for Cancer Immune Therapy (CCIT), Copenhagen University Hospital, Herlev, Denmark

    Evelina Martinenaite, Shamaila Munir Ahmad, Inge Marie Svane & Mads Hald Andersen

  2. Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark

    Mads Hald Andersen

Authors
  1. Evelina Martinenaite
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  2. Shamaila Munir Ahmad
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  3. Inge Marie Svane
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  4. Mads Hald Andersen
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Correspondence to Evelina Martinenaite or Mads Hald Andersen.

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Martinenaite, E., Ahmad, S.M., Svane, I.M. et al. Peripheral memory T cells specific for Arginase-1. Cell Mol Immunol 16, 718–719 (2019). https://doi.org/10.1038/s41423-019-0231-3

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  • DOI: https://doi.org/10.1038/s41423-019-0231-3

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