Review Article | Published:

Targeting natural killer cells in solid tumors

Cellular & Molecular Immunologyvolume 16pages415422 (2019) | Download Citation

Abstract

Natural killer (NK) cells are innate lymphoid cells endowed with cytolytic activity and a capacity to secrete cytokines and chemokines. Several lines of evidence suggest that NK cells play an important role in anti-tumor immunity. Some therapies against hematological malignacies make use of the immune properties of NK cells, such as their ability to kill residual leukemic blasts efficiently after conditioning during haploidentical hematopoietic stem cell transplantation. However, knowledge on NK cell infiltration and the status of NK cell responsiveness in solid tumors is limited so far. The pro-angiogenic role of the recently described NK cell-like type 1 innate lymphoid cells (ILC1s) and their phenotypic resemblance to NK cells are confounding factors that add a level of complexity, at least in mice. Here, we review the current knowledge on the presence and function of NK cells in solid tumors as well as the immunotherapeutic approaches designed to harness NK cell functions in these conditions, including those that aim to reinforce conventional anti-tumor therapies to increase the chances of successful treatment.

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Acknowledgements

The laboratory of E.V. is supported by funding from the European Research Council (ERC) under the European Union Horizon 2020 research and innovation program (Targeting innate lymphoid cells (TILC), grant agreement number 694502), the Agence Nationale de la Recherche (PIONeeR Project (ANR-17-RHUS-0007)), Equipe Labellisée “La Ligue”, Ligue Nationale contre le Cancer, MSDAvenir, Innate Pharma and institutional grants to the CIML (Institut National Français de Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS) and Aix-Marseille University) and to Marseille Immunopôle.

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  1. Innate Pharma, Marseille, France

    • Guillaume Habif
    • , Pascale André
    •  & Eric Vivier
  2. Aix Marseille Université, INSERM, CNRS, Centre d’Immunologie de Marseille-Luminy, Marseille, France

    • Adeline Crinier
    • , Eric Vivier
    •  & Emilie Narni-Mancinelli
  3. Service d’Immunologie, Marseille Immunopole, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France

    • Eric Vivier

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Competing interests

G.H., P.A. and E.V. are employees of Innate Pharma. The other authors declare no competing interests.

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Correspondence to Emilie Narni-Mancinelli.

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https://doi.org/10.1038/s41423-019-0224-2