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Biochemical mechanisms implemented by human acute myeloid leukemia cells to suppress host immune surveillance

Cellular & Molecular Immunology volume 15, pages 989–991 (2018)Cite this article

Abstract

Acute myeloid leukaemia (AML) is a blood/bone marrow cancer originating from myeloid cell precusors capable of self-renewing. AML cells implement biochemical mechanisms which allow them not only to survive, but also to successfully escape immune surveillance. ln this work, we discuss crucial molecular mechanisms used by human AML cells in order to evade immune attack.

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Authors and Affiliations

  1. Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, UK

    Inna M. Yasinska, Isabel Gonçalves Silva, Svetlana Sakhnevych & Vadim V. Sumbayev

  2. Department of Dermatology and Allergy, University of Oldenburg, Oldenburg, Germany

    Bernhard F. Gibbs & Ulrike Raap

  3. Department of Pediatric Surgery and Department of Biomedical Research, Children’s Hospital, Inselspital, University of Bern, Bern, Switzerland

    Elizaveta Fasler-Kan

  4. Department of Biomedicine University Hospital Basel and University of Basel, Basel, Switzerland

    Elizaveta Fasler-Kan

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  1. Inna M. Yasinska
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  7. Vadim V. Sumbayev
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Correspondence to Vadim V. Sumbayev.

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Yasinska, I.M., Gonçalves Silva, I., Sakhnevych, S. et al. Biochemical mechanisms implemented by human acute myeloid leukemia cells to suppress host immune surveillance. Cell Mol Immunol 15, 989–991 (2018). https://doi.org/10.1038/s41423-018-0047-6

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