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Role of Hippo signaling in regulating immunity

Cellular & Molecular Immunology volume 15, pages 1003–1009 (2018)Cite this article

Abstract

The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In particular, patients bearing a loss-of-function mutation of MST1 are reported to have an autosomal recessive primary immunodeficiency syndrome. MST1/2 kinases, the mammalian orthologs of Drosophila Hippo, may activate the non-canonical Hippo signaling pathway via MOB1A/B and/or NDR1/2 or cross-talk with other essential signaling pathways to regulate both innate and adaptive immunity. In this review, we present and discuss recent findings of cellular mechanisms/functions of Hippo signaling in the innate immunity in Drosophila and in mammals, T cell immunity, as well as the implications of Hippo signaling for tumor immunity.

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Fig. 1: The Hippo pathway plays critical roles in the innate immune regulation.
Fig. 2: Hippo signaling plays vital roles in T cell proliferation, migration and differentiation.

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Acknowledgements

This work was supported by grants from National Key R&D Program of China (2017YFA0504502 to D.Z. and L.C., 2015CB910502 to L.C.), The National Natural Science Foundation of China (U1405225 to L.C.; 31625010, 81790254, and U1505224 to D.Z.; 81472229 to L.H.; 81302529 to X.L.), and the Fundamental Research Funds for the Central Universities of China-Xiamen University (20720180047 to L.C., 20720160071 to D.Z., and 20720160054 to L.H.).

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  1. These authors contributed equally: Lixin Hong, Xun Li.

Authors and Affiliations

  1. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Fujian, 361102, Xiamen, China

    Lixin Hong, Dawang Zhou, Jing Geng & Lanfen Chen

  2. Department of Laboratory Medicine, The First Affiliated Hospital, Medical College of Xiamen University, Fujian, 361003, Xiamen, China

    Xun Li

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  1. Lixin Hong
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Correspondence to Lanfen Chen.

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Hong, L., Li, X., Zhou, D. et al. Role of Hippo signaling in regulating immunity. Cell Mol Immunol 15, 1003–1009 (2018). https://doi.org/10.1038/s41423-018-0007-1

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