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When worlds collide: Th17 and Treg cells in cancer and autoimmunity

Cellular & Molecular Immunologyvolume 15pages458469 (2018) | Download Citation

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Abstract

The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent factor in regulating autoimmunity and cancer. Th17 cells are vital for host defense against pathogens but have also been implicated in causing autoimmune disorders and cancer, though their role in carcinogenesis is less well understood. Tregs are required for self-tolerance and defense against autoimmunity and often correlate with cancer progression. This review addresses the importance of a functional homeostasis between these two subsets in health and the consequences of its disruption when these forces collide in disease. Importantly, we discuss the ability of Th17 cells to mediate cancer regression in immunotherapy, including adoptive transfer and checkpoint blockade therapy, and the therapeutic possibilities of purposefully offsetting the Th17/Treg balance to treat patients with cancer as well as those with autoimmune diseases.

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Acknowledgements

This work was supported in part by NIH Training grant T32 GM08716 to H.M.K., NIH Fellowship grant F31 CA192787 to S.R.B., NIH Training grant T32 AI132164-01 to C.J.D., NCI Grants R01 CA175061 and R01 CA208514, KL2 South Carolina Clinical & Translational Research grant UL1 TR000062, ACS-IRG grant 016623-004 and MUSC Start-up funds to C.M.P.

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  1. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA

    • Hannah M. Knochelmann
    • , Connor J. Dwyer
    • , Stefanie R. Bailey
    • , Sierra M. Amaya
    •  & Chrystal M. Paulos
  2. Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC, USA

    • Hannah M. Knochelmann
    • , Connor J. Dwyer
    • , Stefanie R. Bailey
    • , Sierra M. Amaya
    • , Dirk M. Elston
    • , Joni M. Mazza-McCrann
    •  & Chrystal M. Paulos

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The authors declare that they have no competing interest.

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Correspondence to Hannah M. Knochelmann or Chrystal M. Paulos.

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https://doi.org/10.1038/s41423-018-0004-4