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The coordinates and maps associated with data reported in this manuscript have been deposited to the Electron Microscopy Data Bank (EMDB) and Protein Data Bank (PDB) under accession numbers EMD-36322 and PDB 8JIO, respectively.
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We thank the Center of Cryo-Electron Microscopy, Fudan University, for the support on cryo-EM data collection. This work was supported by the National Natural Science Foundation of China (32370995 and 31771008 to J.H. and 3197014 to Z.C.), the Shanghai Municipal Science and Technology Major Project (ZD2021CY001 to J.H.), the Ministry of Science and Technology of China (2021YFC2302500 to L.S.), the National Youth Talent Support Program (2022 to F.W.), the “Shuguang Program” of Shanghai Education Development Foundation and Shanghai Municipal Education Commission (22SG16 to F.W.), Guangzhou Laboratory (SRPG22-003 to L.S.), the National Science and Technology Major Projects of China (2017ZX10202102 to J.H. and 2018ZX10301403 to F.W.).
The authors declare no competing interests.
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Ma, Y., Mao, Q., Wang, Y. et al. A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity. Cell Res (2023). https://doi.org/10.1038/s41422-023-00880-6