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YBX2-dependent stabilization of oocyte mRNA through a reversible sponge-like cortical partition

Cell Research volume 33, pages 640–643 (2023)Cite this article

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Fig. 1: YBX2 formed a reversible SLCP in oocytes stabilizing oocyte mRNA.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (82288102), the National Key R&D Program for Young Scientists (2022YFC2702300), the National Key R&D Program of China (2021YFC2700100) and the National Natural Science Foundation of China (32130029, 82171643, 81971450, 82001538, 81971382).

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Author notes

  1. These authors contributed equally: Zhihua Zhang, Ruyi Liu, Hongbin Zhou.

Authors and Affiliations

  1. Institute of Pediatrics, Children’s Hospital of Fudan University, the Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China

    Zhihua Zhang, Ruyi Liu, Hongbin Zhou, Yuxi Luo, Jian Mu, Tianyu Wu, Qing Sang & Lei Wang

  2. Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China

    Jing Fu

  3. NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, China

    Biaobang Chen

Authors
  1. Zhihua Zhang
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  2. Ruyi Liu
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  3. Hongbin Zhou
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Contributions

Z.Z., Q.S., and L.W. conceived and designed the study. Z.Z., R.L., and H.Z. performed the experiments and bred the mice. J.F. contributed to the collection of human GV oocytes. R.L. performed the oocyte microinjection. Y.L. and H.Z. constructed the plasmids. T.W. provided assistance with the confocal imaging. B.C. and J.M. provided assistance with the experiments and data analysis. Z.Z., Q.S., and L.W. wrote the manuscript.

Corresponding authors

Correspondence to Zhihua Zhang, Qing Sang or Lei Wang.

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The authors declare no competing interests.

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Zhang, Z., Liu, R., Zhou, H. et al. YBX2-dependent stabilization of oocyte mRNA through a reversible sponge-like cortical partition. Cell Res 33, 640–643 (2023). https://doi.org/10.1038/s41422-023-00824-0

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