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The electron density maps and the atomic coordinates for F8–A22–E4 machinery in apo (without DNA), with no visible DNA, and with DNA were deposited in Electron Microscopy Data Bank and Protein Data Bank with accession codes EMD-34684 and 8HDZ, EMD-34927 and 8HOY, and EMD-34929 and 8HPA, respectively.
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We are grateful for the excellent support from Dr. Yi Zeng and all members of the cryo-EM center and the core facility of Wuhan University. We thank Thomas Wileman (University of East Anglia) for critical reading of the manuscript. We want to express our gratitude to all our team members for their supports and discussions. We thank financial supports from the National Natural Science Foundation of China (32250710142), and Strategy and Talent Support Program of Wuhan University.
The authors declare no competing interests.
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Xu, Y., Wu, Y., Zhang, Y. et al. Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex. Cell Res (2023). https://doi.org/10.1038/s41422-023-00796-1