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Retractosomes: small extracellular vesicles generated from broken-off retraction fibers

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Fig. 1: Retraction fibers can break into small vesicles.

References

  1. Rilla, K. J. Extracell. Vesicles 10, https://doi.org/10.1002/jev2.12148 (2021).

  2. Ma, L. et al. Cell Res. 25, 24–38 (2015).

  3. Chen, L., Ma, L. & Yu, L. Cell Discov. 5, https://doi.org/10.1038/s41421-018-0078-2 (2019).

  4. Huang, Y. et al. Nat. Cell Biol. 21, 991–1002 (2019).

  5. Zhao, X. et al. Cell Discov. 5, https://doi.org/10.1038/s41421-019-0093-y (2019).

  6. Thery, C., Amigorena, S., Raposo, G. & Clayton, A. Curr. Protoc. Cell Biol. Chapter 3:Unit 3.22 (2006).

  7. Jiao, H. et al. Cell 184, 2896–2910.e13 (2021).

  8. Jiang, D. et al. Nat. Cell Biol. 21, 966–977 (2019).

  9. Zhu, M. et al. Cell Res. 31, 237–240 (2021).

Download references

Acknowledgements

This research was supported by the Ministry of Science and Technology of China (2017YFA0503404), the National Natural Science Foundation of China (92054301, 31790401, and 32030023), and Beijing Municipal Science & Technology Commission (Z201100005320019). We thank the State Key Laboratory of Membrane Biology, SLSTU-Nikon Biological Imaging Center, Core Facility, Center of Biomedical Analysis, Tsinghua University, for technical support.

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L.Y. and Y.W. conceived the experiments. Y.W. and D.W. performed the cell biology and biochemical experiments. S.G. performed the label free quantitative mass spectrum, and Y.L., C.C.L.W. and Y.C. analyzed the mass spectrum data. B.L. and D.J. performed the in vivo experiments. L.Y. supervised the project. L.Y. and Y.W. wrote the manuscript. All authors discussed the manuscript, commented on the project and contributed to manuscript preparation.

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Correspondence to Li Yu.

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The authors declare no competing interests.

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Wang, Y., Gao, S., Liu, Y. et al. Retractosomes: small extracellular vesicles generated from broken-off retraction fibers. Cell Res (2022). https://doi.org/10.1038/s41422-022-00666-2

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