a Experimental scheme and experimental parameters. Two pre-infected and two control (C1 and C2) RMs were intratracheally inoculated with 1 × 106 TCID50 of SARS-CoV-2. Disease parameters were measured including changes of body weight, body temperature and behaviors at the indicated time points. Viral loads in blood and swabs were monitored to evaluate viral replication kinetics in RMs. Body weight (b) and body temperature (c) were monitored at the indicated time points. d Viral load from oropharyngeal swabs were monitored by qRT-PCR. L.O.D. limit of detection, 200 copies/mL.