Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: METTL4 is an internal m6Am methyltransferase regulating RNA splicing.


  1. 1.

    Boccaletto, P. et al. Nucleic Acids Res. 46, D303–D307 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    Shi, H., Wei, J. & He, C. Mol. Cell 74, 640–650 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Akichika, S. et al. Science 363, eaav0080 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Boulias, K. et al. Mol. Cell 75, 631–643 e638 (2019).

    CAS  Article  Google Scholar 

  5. 5.

    Sendinc, E. et al. Mol. Cell 75, 620–630 e629 (2019).

    CAS  Article  Google Scholar 

  6. 6.

    Sun, H., Zhang, M., Li, K., Bai, D. & Yi, C. Cell Res. 29, 80–82 (2019).

    CAS  Article  Google Scholar 

  7. 7.

    Mauer, J. et al. Nat. Chem. Biol. 15, 340–347 (2019).

    CAS  Article  Google Scholar 

  8. 8.

    Bujnicki, J. M., Feder, M., Radlinska, M. & Blumenthal, R. M. J. Mol. Evol. 55, 431–444 (2002).

    CAS  Article  Google Scholar 

  9. 9.

    Ma, C. et al. Nat. Cell Biol. 21, 319–327 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Kweon, S. M. et al. Mol. Cell 74, 1138–1147 e1136 (2019).

    CAS  Article  Google Scholar 

  11. 11.

    Greer, E. L. et al. Cell 161, 868–878 (2015).

    CAS  Article  Google Scholar 

  12. 12.

    Wei, J. et al. Mol. Cell 71, 973–985 e975 (2018).

    CAS  Article  Google Scholar 

  13. 13.

    Reddy, R., Henning, D., Epstein, P. & Busch, H. Nucleic Acids Res. 9, 5645–5658 (1981).

    CAS  Article  Google Scholar 

  14. 14.

    Lee, Y. & Rio, D. C. Annu. Rev. Biochem. 84, 291–323 (2015).

    CAS  Article  Google Scholar 

Download references


We thank Chunmei Li, Matthew Harris, Erdem Sendinc, and David Valle-Garcia for insightful advice. Y.S. is supported by BCH funds. R.I.G. is a recipient of the NCI Outstanding Investigator Award (R35 CA232115-01). E.A.O. was supported by the Pew Latin American Fellows Program and by a Damon Runyon Fellowship (DRG-2378-19). Y.X. is supported by NIH grants (R01GM088342 and R01GM121827). Y.S. is an American Cancer Society Research Professor.

Author information




Y.S. and H.C. conceived and designed the project. H.C., L.G., J.G. and Q.L. carried out most of the biochemical and cellular experiments. Y.W. performed the bioinformatic analysis under supervision of Y.X. E.A.O. performed m6A Northwestern analysis under supervision of R.I.G. L.W. and Z.S. contributed to characterization of enzymatic activity under supervision of H.W. Y.S. supervised the project throughout. Y.S. and H.C. co-wrote the manuscript and all authors contributed to manuscript writing.

Corresponding author

Correspondence to Yang Shi.

Ethics declarations

Competing interests

R.I.G. is a co-founder, scientific advisory board member, and equity holder of 28-7 Therapeutics. Y.X. is a scientific cofounder of Panorama Medicine. Y.S. is a co-founder and equity holder of Constellation Pharmaceuticals, Inc., a consultant of Guangzhou BeBetter Medicine Technology Co., LTD and an equity holder of Imago Biosciences. All other authors declare no competing financial interests.

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Chen, H., Gu, L., Orellana, E.A. et al. METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell Res 30, 544–547 (2020).

Download citation

Further reading


Quick links