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Acknowledgements
This work was supported by grants from the state Key Program of National Natural Science Foundation of China (31430022), the Strategic Priority Research Program of the Chinese Academy of Sciences, China (XDA16010500), CAS Key Research Projects of the Frontier Science (QYZDY-SSW-SMC027), and the NSFC consulting grant (91753000), the National Natural Science Foundation of China (31625016, 31970597). The Sun Lab was supported by Tsinghua University Initiative Scientific Research Program, Tsinghua-Peking Joint Center for Life Sciences, and the 1000 Young Talent Program of China. W.X. was supported by postdoctoral fellowship from Tsinghua-Peking Joint Center for Life Sciences. The Ren Lab was Supported by CAS Pioneer Hundred Talents Program. We thank H.L.W. and C.L at Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, for their support for UHPLC-MRM-MS/MS analysis.
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Contributions
Y.G.Y., Q.S. and J.R. conceived the project and supervised all the experiments; X.Y. and Q.L.L. performed most experiments with help from Y.Y., J.C. and L.F.J.; X.Y., W.X., Q.L.L. and Y.Y. performed high-throughput sequencing; Y.C.Z. and W.X. performed bioinformatics analysis with the help of K.L. and Y.S.C.; Y.G.Y, Q.S., J.R., Y.Y., X.Y. and W.X. analyzed the data and wrote the manuscript.
Corresponding authors
Correspondence to Jie Ren or Qianwen Sun or Yun-Gui Yang.
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The authors declare no competing interests.
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Yang, X., Liu, Q., Xu, W. et al. m6A promotes R-loop formation to facilitate transcription termination. Cell Res 29, 1035–1038 (2019). https://doi.org/10.1038/s41422-019-0235-7
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