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Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome

Cell Researchvolume 29pages330333 (2019) | Download Citation

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Acknowledgements

We thank staffs from the Electron Microscopy System and the Database and Computation System of the National Facility for Protein Science in Shanghai (NFPS), Zhangjiang Lab for their assistance with the EM instruments and data pre-processing. We are grateful to the NFPS Large-scale Protein Preparation System and Mass Spectrometry System for instrument support and technical assistance. This work was supported by the National Key R&D Program of China (2016YFA0501803 and 2017YFA0504504), the National Natural Science Foundation of China (31570766 and U1632130), the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (2017YZ004), the SHIPM-sigma fund (BJ1–7009–18–1303 and JY201805) from Shanghai Institute of Precision Medicine, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, and Chinese Academy of Sciences Facility-based Open Research Program. J.H. is a recipient of the Thousand Young Talents Program of China and a recipient of the Hundred Talents Program of Shanghai Jiao Tong University School of Medicine.

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Affiliations

  1. State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 201210, China

    • Tonghui Yao
    • , Wei Jing
    •  & Zhiguo Hu
  2. Shanghai Institute of Precision Medicine, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    • Ming Tan
    • , Mi Cao
    • , Qianmin Wang
    • , Guiyong Yuan
    • , Ming Lei
    •  & Jing Huang
  3. National Facility for Protein Sciences in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210, China

    • Yan Li

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Contributions

T.Y. performed sample preparation, EM data collection and biochemical analyses; W.J. and Z.H. helped with protein purifications; G.Y. helped with nucleosome preparation; M.T., M.C., Q.W., and Y.L. helped with EM data analyses; M.L. and J.H. initiated the project; J.H. designed and supervised all the research, and wrote the manuscript with help from all other authors.

Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Jing Huang.

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https://doi.org/10.1038/s41422-019-0146-7