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TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer

Cell Researchvolume 29pages248250 (2019) | Download Citation

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  1. 1.

    He, Y. F. et al. Science 333, 1303–1307 (2011).

  2. 2.

    Wu, X. & Zhang, Y. Nat. Rev. Genet. 18, 517–534 (2017).

  3. 3.

    Wu, D. et al. Nature 559, 637–641 (2018).

  4. 4.

    Forbes, S. A. et al. Nucleic Acids Res. 45, D777–D783 (2017).

  5. 5.

    Desai, P. et al. Nat. Med. 24, 1015–1023 (2018).

  6. 6.

    Vella, P. et al. Mol. Cell 49, 645–656 (2013).

  7. 7.

    Esteve, P. O. et al. Nucleic Acids Res. 44, 1642–1656 (2016).

  8. 8.

    Morrison, D. K. Trends Cell Biol. 19, 16–23 (2009).

  9. 9.

    Zhao, J., Meyerkord, C. L., Du, Y., Khuri, F. R. & Fu, H. Semin. Cell & Dev. Biol. 22, 705–712 (2011).

  10. 10.

    Gwinn, D. M. et al. Mol. Cell 30, 214–226 (2008).

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The authors would like to thank Barry Zee, Tobin Gramyk, George Murphy and Christine Lian for critical reading of the manuscript and insightful comments, Guoming Shi, Jia Fan, Fei Lan and Lingchun Kong for their help and advice in experimental design, Anna Payne-Tobin Jost and Jennifer Waters of NIC at Harvard for the supports in imaging, and Santa Cruz Biotechnology, Inc. for providing antibodies. This work was supported by NIH grants GM112062 and CA194302 to Y.G.S.

Author information


  1. Laboratory of Epigenetics, Liver Cancer Institute, Zhongshan Hospital, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China

    • Hao Chen
    • , Dingdang Yu
    •  & Yujiang Geno Shi
  2. Division of Newborn Medicine and Program in Epigenetics, Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA

    • Hao Chen
    •  & Yang Shi
  3. Endocrinology Division, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA

    • Rui Fang
    • , Kimberlie Rabidou
    • , Di Wu
    • , Di Hu
    •  & Yujiang Geno Shi
  4. Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA

    • Peilin Jia
    •  & Zhongming Zhao
  5. Departments of Structural Biology and Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA

    • Zhiping Wu
    •  & Junmin Peng


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H.C. and Y.G.S. conceived and designed the study. H.C., D.Y., K.M., R.F., D.W. and D.H. performed most of the experiments. P.J. and Z.Z. carried out the MSEA analysis. Z.W. and J.P. were responsible for mass spectrometry determination. H.C. and Y.G.S. wrote the manuscript and all authors contributed to the final version of the manuscript. Y.S. and Y.G.S. supervised the project.

Competing interests

Y.S. is a co-founder of Constellation Pharmaceuticals and Athelas Therapeutics, and a consultant for Active Motif, Inc. Remaining authors declare no competing financial interests.

Corresponding author

Correspondence to Yujiang Geno Shi.

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