Table 2 Correlation between nuclear USP43 level and the clinicopathologic characteristics of breast carcinomas

From: Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis

Variables n Nuclear USP43 level p-Value
Positive (n, %) Negative (n, %)
Histological grade
  II 101 52 (74.29%) 49 (57.65%) p=0.023
  III 54 18 (25.71%) 36 (42.35%)
Age (years)
  ≥55 81 34 (46.58%) 47 (57.32%) p=0.181
  <55 74 39 (53.42%) 35 (42.68%)
Location
  Left 87 41 (54.67%) 46 (58.23%) p=0.745
  Right 67 34 (45.33%) 33 (41.77%)
Tumor size (cm)
  D ≤ 3.3 94 57 (79.17%) 37 (44.58%) p<0.001
  D > 3.3 61 15 (20.83%) 46 (55.42%)
Depth of invasion
  T0 and T1 40 28 (39.44%) 12 (14.63%) p<0.001
  T2 103 42 (59.15%) 61 (74.39%)
  T3 10 1 (1.41%) 9 (10.98%)
Lymph node
  N0 78 45 (60.81%) 33 (40.74%) p=0.044
  N1 43 16 (21.62%) 27 (33.33%)
  N2 and N3 34 13 (17.57%) 21 (25.93%)
TNM stage
  I 26 21 (29.58%) 5 (6.17%) p<0.001
  II 87 37 (52.11%) 50 (61.73%)
  III 39 13 (18.31%) 26 (32.10%)