Fig. 1 | Cell Research

Fig. 1

From: Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

Fig. 1

Diverse molecular functions of m6A. In eukaryotic cells, RNA m6A level is dynamically regulated by “writers” and “erasers”, and recognized by “readers” in direct or indirect ways. The diversity of cellular processes involving m6A is mainly contributed by various “readers”. The nuclear m6A modulates a mRNA alternative splicing,5,7,8,9,11,12,13,14,15,54,58,59,60 b secondary structure switching,5,11,105 c mRNA export,17,18 d pri-miRNA processing,104,135 e mRNA stability24 and f XIST-dependent X chromosome inactivation,57 while the cytoplasmic m6A (g and h) enhances mRNA translation efficiency26,27,29,32,106 and i accelerates mRNA decay.20,21,23,108

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