Fig. 1: Histopathological and virological analyses of skin tissues from deceased patients with COVID-19. | Cell Discovery

Fig. 1: Histopathological and virological analyses of skin tissues from deceased patients with COVID-19.

From: Infection of human sweat glands by SARS-CoV-2

Fig. 1

a Hematoxylin and eosin staining of skin tissue sections (i–iv). The green and blue arrows indicate necrotic cells in the epidermis and lymphocyte infiltration in the dermis, respectively. b Analysis of the immune response in skin tissues. Immunohistochemical staining for inflammatory cell markers, including CD3+, CD8+ T lymphocytes, and CD68+ macrophages. c SARS-CoV-2 detection in skin tissue. Immunohistochemical and immunofluorescence analyses of SARS-CoV-2 infection in sweat glands (i) and sweat ducts (ii). d Characterization of cells targeted for SARS-CoV-2 infection and correlation between cell tropism and receptor distribution in the skin. Multicolor immunofluorescence staining of SARS-CoV-2 spike protein (red), cell markers of secretory luminal cells (Krt7; cyan) and basal cells (Krt5; magenta), ACE2 receptor (green), and TMPRSS2 coreceptor (gray). The right panels are enlarged images of the respective colored boxes on the left. Arrows indicate representative positive signals for viral spike. e Electron microscopy of viral particles (arrows) in the skin cell. f Schematic of SARS-CoV-2 infection in the skin.

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