Fig. 1: NR4A1 knockout mice exhibits decreased MKP7 expression, abnormal insulin response, and increased JNK activation. | Cell Death Discovery

Fig. 1: NR4A1 knockout mice exhibits decreased MKP7 expression, abnormal insulin response, and increased JNK activation.

From: NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving

Fig. 1

A The relative mRNA levels of MKP7 in the islets from WT and KO mice fed with normal diet were assayed with qPCR. B The relative protein level of MKP7 in the islets from WT or KO mice fed with a normal diet was obtained with Western Blotting. After 4 months of high-fat diet feeding, WT and KO mice were tested for the basal blood glucose level (C) and GTT (D). The relative p-JNK levels and the relative MKP7 levels in the islets from WT or KO mice fed with a high-fat diet for four months were analyzed (EF). These data represented the means of three independent experiments, *P < 0.05, **P < 0.01, ***P < 0.001 vs. ns. Error bars were shown as SD values.

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