A CCK-8 was used to detect cell viability; B ELISA was used to detect the levels of IL-1β and IL-18 in cells; C western blot was used to detect the levels of pyroptosis markers in cells. Nig represents an activator of NLRP3. *p < 0.05, **p < 0.01, ***p < 0.001. All experiments were performed three times independently. Data were analyzed using two-way ANOVA and Tukey’s multiple comparison test.