Fig. 1: Pristimerin inhibits cell growth and induces cell cycle G1 arrest in breast cancer cells. | Cell Death Discovery

Fig. 1: Pristimerin inhibits cell growth and induces cell cycle G1 arrest in breast cancer cells.

From: Pristimerin induces apoptosis and autophagy via activation of ROS/ASK1/JNK pathway in human breast cancer in vitro and in vivo

Fig. 1

a MDA-MB-231 and MDA-MB-468 cells were treated with various concentrations of pristimerin for 24, 48, and 72 h. Cell viability was analyzed by MTT assay. b The effect of pristimerin on normal human breast epithelial cells of the MCF-10A line is shown. c The results from the colony formation assay of MDA-MB-231 and MDA-MB-468 cells after pristimerin treatment are shown. d MDA-MB-231 and MDA-MB-468 cells were treated with pristimerin for 24 h, and the cell cycle distribution percentages were analyzed by flow cytometry. e The cells were treated with various concentrations of pristimerin for 24 h, and the expression of cell cycle-regulated proteins was detected by Western blotting. Results from three independent experiments are presented. *P < 0.05, **P < 0.01 and ***P < 0.001 versus control, #P < 0.05, ##P < 0.01 and ###P < 0.001 versus pristimerin treatment

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