Retraction Note to: Cell Death & Disease
https://doi.org/10.1038/s41419-018-1235-0 published online 11 December 2018
The Editors-in-Chief have retracted this article at the request of Imperial College London. An investigation concluded that there are a number of concerns with this article, specifically:
Figure 2B represented technical repeats, and not biological repeats as is implied by the legend.
Figure 4A: the second and third panel representing results of the KKU-D131 cells have been altered to bring them more in line with other test results, though this was not declared in the article. Additionally, similar concerns were also raised regarding the 5th and 6th bars in the E2F1 mRNA and TYMS mRNA panels.
Figure 7B: the underlying data for this figure has been manipulated.
The article suggests that the Western blots and RT-qPRC results in Figures 4 and 7 came from contemporaneous experiments. However, the investigation found that the western blotting and the mRNA determinations had been performed by different researchers more than a year apart.
Paula Saaveedra Garcia and Chun-Fui Lai agree with this retraction. Eric Lam, Stafania Zona, Kulthida Vaeteewoottacharn, Chawalit Pairojkul, Sakda Waraasawapati, Vor Luvira, Sopit Wongkham, Somchai Pinlaor and Kitti Intuyod disagree with this retraction. Shang Yao, Jay-Sze Yong, Sasanan Trakansuebkul and Yannasittha Jiramongkol have not responded to correspondence regarding this retraction.
Edited by P. Bouillet
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Intuyod, K., Saavedra-García, P., Zona, S. et al. Retraction Note to: FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1–TYMS axis uncoupling in 5-FU resistance. Cell Death Dis 12, 539 (2021). https://doi.org/10.1038/s41419-021-03807-4