Fig. 6: POU2F2 promotes aerobic glycolysis via PDPK1-dependent activation of PI3K/AKT/mTOR pathway. | Cell Death & Disease

Fig. 6: POU2F2 promotes aerobic glycolysis via PDPK1-dependent activation of PI3K/AKT/mTOR pathway.

From: POU2F2 regulates glycolytic reprogramming and glioblastoma progression via PDPK1-dependent activation of PI3K/AKT/mTOR pathway

Fig. 6

A Immunoblotting of POU2F2, PDPK1, AKT, p-AKT, mTOR, and p-MTOR in shCtrl, shPOU2F2, and shPOU2F2/PDPK1 cells with or without NSC156529 treatment (20 μM). B Glucose uptake in GBM cells with different treatment. C Glucose consumption in GBM cells with different treatment. D Glycolytic flux changes in GBM cells with different treatment. E Lactate production in GBM cells with different treatment. F Lactate dehydrogenase activity in GBM cells with different treatment. G Immunoblotting of GLUT1, HK2, and PKM2 in shCtrl, shPOU2F2, and shPOU2F2/PDPK1 cells with or without NSC156529 treatment. All data were shown as the mean ± SD, **p < 0.01.

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