Fig. 7: A hypothetical model depicting recruitment and stabilization of hop kinase transcripts by RNA helicase Mahe which leads to activation of JAK/STAT signaling and primes hid mediated apoptosis. | Cell Death & Disease

Fig. 7: A hypothetical model depicting recruitment and stabilization of hop kinase transcripts by RNA helicase Mahe which leads to activation of JAK/STAT signaling and primes hid mediated apoptosis.

From: Maheshvara regulates JAK/STAT signaling by interacting and stabilizing hopscotch transcripts which leads to apoptosis in Drosophila melanogaster

Fig. 7

Our model depicts that Mahe encoding an RNA helicase binds and regulates hop transcript stability, and this results in the increase in levels of Hop kinase. This upregulation of Hop tyrosine kinase leads to enhanced phosphorylation and activation of transcription factor Stat92E which enters into the nucleus, resulting in downstream target gene activation. An auto feedback loop is reflected by increase in the levels of Upd2, and thus the JAK/STAT signaling remains in an active state. This activated JAK/STAT signaling then induces hid mediated apoptosis.

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