Fig. 3: Overexpression of HOXC6 promotes the migration and invasion of CRC cells in vitro and in vivo. | Cell Death & Disease

Fig. 3: Overexpression of HOXC6 promotes the migration and invasion of CRC cells in vitro and in vivo.

From: HomeoboxC6 promotes metastasis by orchestrating the DKK1/Wnt/β-catenin axis in right-sided colon cancer

Fig. 3

A Transwell experiments with and without matrigel with HCT116 cells in the NC HOXC6-KD and HOXC6-OE groups. Scale bars indicate 100 µm. B Numbers of invading HCT116 cells in the NC, HOXC6-KD, and HOXC6-OE groups. C Numbers of migrating HCT116 cells in NC, HOXC6-KD, and HOXC6-OE groups. D Transwell experiments with and without matrigel of RKO cells in the NC HOXC6-KD and HOXC6-OE groups. E Numbers of invading RKO cells in the NC HOXC6-KD and HOXC6-OE groups. F Numbers of migration RKO cells in the NC HOXC6-KD and HOXC6-OE groups. G Schematic diagram of a metastatic tumor model of nude mice with tumor cells injected into the tail vein. H The number of metastatic foci in mouse lungs in the NC and HOXC6-OE HCT116 groups. I Images of isolated mouse lungs in the NC and HOXC6-OE HCT116 groups. J HE staining images of mouse lungs in the NC and HOXC6-OE HCT116 groups. *: P < 0.05; **: P < 0.01; ***: P < 0.001. n.s.: no significance.

Back to article page