A No difference in HOXC6 expression was observed between CRC and normal tissues by using TCGA samples. B HOXC6 was overexpressed in RCC but not in LCC compared to normal colon tissues based on TCGA samples. C Left: Western blot of fresh-frozen tissues from RCC and LCC showed that HOXC6 was overexpressed in RCC but not in LCC compared to paired adjacent normal colon tissues. Right: Adjusted mean gray values by control gray values of WB. D. KM plot showing that HOXC6 high-expression group had poor prognosis compared to the low-expression group in RCC. E The KM plot showed that there was no prognostic difference between the HOXC6 high-expression and low-expression groups in LCC. F KM plot showing that the HOXC6 high-expression group had a poor prognosis compared to the low-expression group in the ZUCI RCC samples (n = 100). G Representative images of the HOXC6 high-expression and low-expression groups. Scale bars indicate 100 µm. *: P < 0.05.