Fig. 2: BP-1-102 maintained elastin structure and volume, and reduced MMPs expressions. | Cell Death & Disease

Fig. 2: BP-1-102 maintained elastin structure and volume, and reduced MMPs expressions.

From: A novel STAT3 inhibitor attenuates angiotensin II-induced abdominal aortic aneurysm progression in mice through modulating vascular inflammation and autophagy

Fig. 2

a. Elastin structure of aortic wall was evaluated at indicated time points using Weigert’s resorcin-fuchsin elastic staining. Saline treated group was used as control (mock) (left). Elastin degradation was prevented in AngII+ BP-1-102+ group (AngII+BP+, lower panel) compared with AngII+ group (upper panel) at each time point. b. Mean aortic wall elastin volume of AngII+ group (red column) and AngII+ BP-1-102+ group (AngII+BP+, blue column) were analyzed at indicated time points. Saline treated group was used as control (green column). Comparing with AngII+ group, the AngII+ BP-1-102+ group showed preserved elastin volume at each time point. The results were presented as mean ± standard deviation (SD). n= 8. *P < 0.01 vs. AngII+ group (two-way ANOVA followed by Tukey’s test). NS indicates non-significant differences compared with AngII+ group. c mRNA expression of MMP-2 was determined using real-time PCR. Fold changes were calculated and statistically analyzed at indicated time points. Saline treated group were used as control (green column). The results were presented as mean ± standard deviation (SD). n= 8. *P < 0.01 vs. AngII+ group (two-way ANOVA followed by Tukey’s test). NS indicates non-significant differences compared with AngII+ group. d mRNA expression of MMP-9 was determined using real-time PCR. Fold changes were calculated and statistically analyzed at indicated time points. Saline treated group were used as control (green column). The results were presented as mean ± standard deviation (SD). n= 8. *P < 0.01 vs. AngII+ group (two-way ANOVA followed by Tukey’s test). NS indicates non-significant differences compared with AngII+ group.

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