Fig. 1: BP-1-102 decreased AAA formation and progression. | Cell Death & Disease

Fig. 1: BP-1-102 decreased AAA formation and progression.

From: A novel STAT3 inhibitor attenuates angiotensin II-induced abdominal aortic aneurysm progression in mice through modulating vascular inflammation and autophagy

Fig. 1

a Eight-week-old male ApoE−/− mice were administrated with AngII (1.44 mg/kg/day) and DSMO-PBS (AngII+ group) or AngII (1.44 mg/kg/day) and BP-1-102 (5 mg/kg) (AngII+ BP-1-102+ group) at indicated time points. Saline administrated was used as control group (mock) (left). Representative images of AAA at each time point were presented. AngII+ BP-1-102+ group (AngII+BP+, lower panel) showed less severity of AAA compared with AngII+ group (upper panel) at each time point. Arrows indicate typical AAA. b The maximum aortic diameter at the infra-diaphragm was measured. The AngII+ BP-1-102+ group (AngII+BP+, blue dots) showed reduced aortic diameter comparing with AngII+ (red dots) at each time point (day 7, day 14, and day 28). The results were presented as mean ± standard deviation (SD). n= 8. *P < 0.01 vs. AngII+ group (two-way ANOVA followed by Tukey’s test). NS indicates non-significant differences compared with AngII+ group. c The incidence of AAA was evaluated on day 28. The AngII+ BP-1-102+ group (blue column) showed reduced incidence of AAA compared with AngII+ group (red column). n= 8. *P < 0.01 vs. AngII+ group (chi‐square test). NS indicates non-significant differences compared with AngII+ group.

Back to article page