Fig. 5: CenTFinder analysis identifies SPI1 and IRF TFs as major LSEC regulators. | Cell Death & Disease

Fig. 5: CenTFinder analysis identifies SPI1 and IRF TFs as major LSEC regulators.

From: PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells

Fig. 5

A Heatmap of the top 20 most upregulated and downregulated genes in LSECs compared to ETV2-ECs. B Heatmap of the top 20 most upregulated and downregulated TFs in LSECs compared to ETV2-ECs. C CenTFinder core analysis results were combined. Each dot represents a TF that was differentially and higher expressed in LSECs compared to ETV2-ECs. In addition, only TFs with kME > 0.5 and NES > 3 were considered. SPI1 was identified as the central TF in the immune response clusters related to cytokine signalling and secretion. IRF TFs were central to the immune response cluster related to inflammasomes. Top TFs are highlighted in red.

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