Fig. 2: MT1DP represses NRF2 via stabilizing miR-365a-3p. | Cell Death & Disease

Fig. 2: MT1DP represses NRF2 via stabilizing miR-365a-3p.

From: MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells

Fig. 2

a The interaction network showed that miR-365a-3p was correlated with MT1DP significantly. b The binding site of miR-365a-3p within MT1DP and 3′-UTR of NRF2. c Interaction between miR-365a-3p and MT1DP was confirmed by RNA pulldown assay. d MT1DP overexpression elevated miR-365a-3p and reduced NRF2. e MT1DP-mediated NRF2 downregulation was abrogated by miR-365a-3p inhibitor. f NRF2 was identified as a target of miR-365a-3p by dual-luciferase reporter assay. g miR-365a-3p mimic decreased NRF2 expression. h miR-365a-3p mimic decreased NRF2 mRNA. All experiments were repeated at least three times and representative data are shown. Data are means ± SEM; **p < 0.01.

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