a The heat map shows genes reporting significantly different expression when various malignant tumor cells were treated with or without ferroptosis inducers (i.e., GSE94550, GSE137952, and GSE122985). R package limma was used to identify the differential expressed genes. b Expression of MT1DP in NSCLC cell lines treated with erastin performed by qPCR. c Silencing of NRF2 decreased cell viability. d Overexpression of NRF2 enhanced cell viability. e Negative correlation between expressions of MT1DP and NRF2 in NSCLC samples. f NRF2 protein expression was abolished by exogenous MT1DP in NSCLC cell lines. g NRF2 expression in A549 and H1299 cells with ectopic expression of MT1DP. h NRF2 were upregulated in A549 and H1299 cells with silence of MT1DP. i NRF2 mRNA expression by qPCR. j Exogenous MT1DP rescued erastin-inhibited cell viability of A549 cell. k Overgeneration of ROS treated with erastin/MT1DP in A549 and H1299 cells. l A549 and H1299 cells treatment with Fer‐1 mitigated erastin/MT1DP‐induced decrease in cell viability. m Exogenous NRF2 in A549 and H1299 cells alleviated reduced cell viability caused by erastin or ectopic MT1DP. All experiments were repeated at least three times and representative data are shown. Data are means ± SEM; *p < 0.05, **p < 0.01.