Fig. 3: Modulation of intracellular calcium levels and PoP3 uptake of RASF after CBD challenge with concomitant inhibition of membrane TRP channels and mitochondrial targets. | Cell Death & Disease

Fig. 3: Modulation of intracellular calcium levels and PoP3 uptake of RASF after CBD challenge with concomitant inhibition of membrane TRP channels and mitochondrial targets.

From: Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts

Fig. 3

Mean intracellular calcium mobilization (a, b, e, f, i, j, m, n, q, r, u, v) and mean PoPo3 uptake (c, d, g, h, k, l, o, p, s, t, w, x) of RASF after CBD challenge and concomitant inhibition with the antagonists given in the figure. n is the number of experiment replicates from 24 patient samples (a, c), 33 patient samples (b, d), and 8 patient samples (n, p). ex (except n, p) n number equals number of replicates and different patient samples. ANOVA with Dunnett’s T3 post-hoc test was used for all comparisons versus (ad). *p < 0.05, ***p < 0.001.

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