Fig. 2: Anlotinib inhibits migration and invasion of ICC cells via inhibition of the epithelial–mesenchymal transition. | Cell Death & Disease

Fig. 2: Anlotinib inhibits migration and invasion of ICC cells via inhibition of the epithelial–mesenchymal transition.

From: Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinoma

Fig. 2

The effects of anlotinib on cell invasion and migration were measured using wound-healing (a) and transwell assays without Matrigel (b) and with Matrigel (c); d after treatment with anlotinib, expression and localization of E-cadherin and N-cadherin markers in HCCC9810 and RBE cells were analyzed using immunofluorescence staining; e the expression of EMT markers (E-cadherin and N-cadherin) in ICC cell lines were detected using qRT-PCR analyses. *P < 0.05; **P < 0.01; ***P < 0.001. Scale bars = 100 μm.

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