Fig. 5: CCL2 is required for BRD4-induced tumor growth. | Cell Death & Disease

Fig. 5: CCL2 is required for BRD4-induced tumor growth.

From: BRD4 promotes tumor progression and NF-κB/CCL2-dependent tumor-associated macrophage recruitment in GIST

Fig. 5

a The indicated cytokines expression in GIST882 cells stably expressing shcon or shBRD4 were analyzed by RT-PCR. b ELISA of CCL2 expression in the GIST882 and GIST-T1 cells stably expressing shcon or shBRD4. c ELISA of CCL2 expression in the GIST882 and GIST-T1 cells stably expressing vector or BRD4. d GIST882 control vector cells or BRD4 cells were subcutaneously injected into Balb/c nude mice. Mice were treated with IgG or αCCL2 antibody. Tumor volume growth curves from day 1 to 19 of treatment are presented. e GIST882 cells stably expressing shcon or shCCL2 with BRD4 overexpression were subcutaneously injected into Balb/c nude mice. Mice were treated with IgG or αCCL2 antibody. Tumor volume growth curves from day 1 to 19 of treatment are presented. *P < 0.05; **P < 0.01.

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