Fig. 7: Apogossypol-mediated ER membrane reorganisation antagonises mitochondrial fission, MOMP and apoptosis. | Cell Death & Disease

Fig. 7: Apogossypol-mediated ER membrane reorganisation antagonises mitochondrial fission, MOMP and apoptosis.

From: Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis

Fig. 7

Apogossypol induces ER membrane reorganisation (top part of the figure). ER membranes are normally in close proximity to mitochondria and mark mitochondrial constriction sites. This is illustrated in the left lower part of the figure, which depicts ER membranes wrapping around a mitochondrion at the constriction site. This site is also marked by the recruitment of DRP-1 monomers, which ultimately form an oligomeric constriction ring thereby facilitating mitochondrial fission. Upon exposure to an apoptotic stress stimulus, cytosolic BAX is activated and is also recruited onto the constriction sites, facilitating MOMP and cytochrome c release, resulting in the induction of apoptosis. Apogossypol-induced ER membrane reorganisation antagonises mitochondrial fission, BAX activation, recruitment on mitochondrial membranes, caspase activation and apoptosis

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