Fig. 7: The promotor role of IFITM3 in PCa cell proliferation and metastasis. | Cell Death & Disease

Fig. 7: The promotor role of IFITM3 in PCa cell proliferation and metastasis.

From: IFITM3 promotes bone metastasis of prostate cancer cells by mediating activation of the TGF-β signaling pathway

Fig. 7

Overexpression of IFITM3 combined with Smad4 promoted Smad2/3 phosphorylation, thereby affecting transcriptional regulation to induce PTHrP-driven bone metastasis. In addition, the TGF-β-Smads pathway had crosstalk with MAPK pathway, thus promoting malignant proliferation of tumor cells by activating the p38-MAPK and ERK pathways, and simultaneously regulating gene transcription level and EMT to facilitate tumor cell metastasis

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