Fig. 7: Schematic of SDT inhibits PA-induced beta cell injury via PINK1/Parkin-dependent mitophagy. | Cell Death & Disease

Fig. 7: Schematic of SDT inhibits PA-induced beta cell injury via PINK1/Parkin-dependent mitophagy.

From: Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy

Fig. 7

In beta cells, PA damages mitochondria and mitophagy. Damaged mitochondria accumulate in cells due to inadequate mitophagy and produce massive ROS, thus promote inflammation and cell apoptosis. SDT restores the PINK1/Parkin-dependent mitophagy through upregulation of PINK1 expression and recruitment of Parkin to mitochondria. Thus, SDT suppresses inflammation and cell apoptosis and promotes insulin secretion. PA palmitic acid, PINK1 PTEN-induced putative kinase 1, ROS reactive oxygen species, SDT sonodynamic therapy

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